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KMID : 0858520100140020095
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Journal of the Korean Society of Magnetic Resonance in Medicine
2010 Volume.14 No. 2 p.95 ~ p.102
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MRI Findings of Triple Negative Breast Cancer: A Comparison with Non-Triple Negative Breast Cancer
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Choi Jae-Jung
Kim Sung-Hun
Cha Eun-Suk
Kang Bong-Joo
Lee Jee-Hye
Lee So-Yeon
Jeong Seung-Hee
Yim Hyeon-Woo
Song Byung-Joo
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Abstract
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Purpose:To evaluate the magnetic resonance imaging (MRI) and clinicopathological features of triple negative breast cancer, and compare them with those of non-triple negative breast cancer.
Materials and Methods :This study included 231 pathologically confirmed breast cancers from January 2007 to May 2008. We retrospectively reviewed the MRI findings according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon: mass or non-mass type, mass shape, mass margin, non-mass distribution, and enhancement pattern. Histologic type, histologic grade, and the results for epidermal growth factor receptor, p53, and Ki 67 were reviewed.
Results:Of 231 patients, 43(18.6%) were triple negative breast cancer. Forty triple negative breast cancers (93.0%) were mass-type lesion on MRI. A round or oval or lobular shape (p=0.006) and rim enhancement (p=0.004) were significantly more in triple negative breast cancer than non- triple negative breast cancer. In contrast, irregular shape (p=0.006) and spiculated margins (p=0.032) were significantly more in non-triple negative breast cancer. Old age (p=0.019), high histologic grade (p<0.0001), EGFR positivity (p<0.0001), p53 overexpression (p=0.038), and Ki 67 expression (<0.0001) were significantly associated with the triple negative breast cancer.
Conclusion:MRI finding may be helpful for differentiation between triple negative and non-triple negative breast cancer.
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KEYWORD
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Breast cancer, Estrogen receptor, Progesterone receptor, HER2, Magnetic resonance imaging (MRI)
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